At the age of 49, Applegate announced her diagnosis of Multiple Sclerosis (MS) in August 2021. Because of the ailment, Applegate had to alter his work methods and deal with physical difficulties on the job. The actress found out about her condition while filming the last season of “Dead to Me,” yet she kept playing the part.

Applegate, suffering from MS, used a wheelchair and cane for mobility and balance. Despite her pain, she chose to leave her job, expressing gratitude for her co-star Linda Cardellini.

“I’m probably not going to work on camera again, but I’m so glad that I went out with someone who is by far the greatest actress I’ve ever worked with in my entire life if not the greatest human I’ve ever known.”

She also struggles with simple tasks like wearing a bra. Applegate praises Kim Kardashian’s clothing brand, Skims, for releasing adaptive clothing for people with mobility issues.

Christina Applegate, who has MS, struggles with her condition and is immunocompromised. She spends most days alone and watches TV in bed, but occasionally seeks help from her family. Her daughter Sadie is cared for by a friend and a caretaker, and she bonds with her mother when she takes her to school.

Christina Applegate, a Hollywood star, recently celebrated her daughter Sadie’s first red-carpet appearance at the 2023 Critics’ Choice Awards. Despite her diagnosis, she has rarely been seen publicly, but she made a special appearance with her daughter. Despite criticism, Applegate has a supportive husband and daughter, and her legacy in film and television remains despite doubts about her future in the industry.